I am writing to acquire some more detailed information about a substance called kynoselen. I know it is used on horses, but in some "hardcore" magazines, it is being promoted for use by humans because of its so called "anabolic effect." How exactly does this work? Beside the fact that it is made for horses not humans, how else is this harmful, if at all?
Kynoselen is a French drug used in horses and dogs to treat muscular dystrophies and as a performance enhancer. It is delivered in an intramuscular form, which limits the problems associated with oral digestion, absorption and delivery. Because strength and size athletes often have a "what is good for a horse must be good for me" attitude, supplement marketers have played upon this by offering a legal, stateside oral preparation called Kyno-H. Although it does contain the same vitamin and mineral core (though I am not certain the amounts are identical), it fails to mention that the equine version contains a drug element called heptaminol, which is conspicuously absent from the supplement. As best as I can tell, heptaminol acts similarly to ephedrine: as a myocardial stimulant and a bronchodilator.
Additionally, it raises blood pressure and affects catecholamine release and calcium metabolism. But as stated, the supplement sold here in the USA does not contain this drug. That leaves the other ingredients as possible agents to enhance performance. These include potassium and magnesium aspartates. Aspartates are used as mineral transporters and may be involved with reducing fatigue. One can certainly make a case for a hard training athlete benefiting from magnesium supplementation. A properly designed multivitamin and mineral formula should cover the athlete's needs for magnesium, as well as B-12 and potassium (other ingredients in Kyno-H). Data on potassium and magnesium aspartate effectiveness is mixed, with positive studies showing fatigue resistance as measured by time to exhaustion. Studies that did show a benefit used high doses (greater than two grams per day).
As is typical in bogus drug rip-off supplements aimed at bodybuilders, the benefits cited relate to the drug and not the supplement. Among the ridiculous, unsubstantiated claims on one web site selling the Kyno-H supplement, one true statement did stand out. It started, "Now, there's no scientific study to prove this..."
In the end, it appears that what is sold is an expensive vitamin and mineral supplement with bogus claims that should be redundant if the athlete is taking a multivitamin and mineral formula.